Table 2:
Type of autoimmune diseases present in primary open angle glaucoma and control patients undergoing ophthalmic surgery
| Predominant Immune Mechanism | POAG % (n = 172) | Controls % (n = 179) | p-value |
|---|---|---|---|
| T-cell mediated | 11.6 | 5.0 | 0.02 |
| • Psoriasis | 4.1 | 2.8 | |
| • Non-infectious anterior uveitis | 2.9 | 0.6 | |
| • Alopecia areata | 1.2 | 0 | |
| • Giant cell arteritis | 0.6 | 0 | |
| • Polymyalgia rheumatica | 1.2 | 0.6 | |
| • Multiple sclerosis | 0.6 | 0 | |
| • Psoriatic arthritis | 0.6 | 1.1 | |
| • Ankylosing spondylitis | 0.6 | 0 | |
| B-cell mediated | 2.9 | 2.8 | >0.99 |
| • Graves’ disease | 1.7 | 0 | |
| • Raynaud’s syndrome | 1.2 | 1.7 | |
| • Systemic lupus erythematosus | 0 | 0.6 | |
| • Meniere’s disease | 0 | 0.6 | |
| Combined T-cell and B-cell mediated | 9.9 | 7.3 | 0.38 |
| • Rheumatoid arthritis | 4.6 | 2.8 | |
| • Juvenile rheumatoid arthritis | 1.2 | 0 | |
| • Inflammatory polyarthropathy (ANA+) | 0.6 | 0 | |
| • Immune thrombocytopenic purpura | 0.6 | 0 | |
| • Hashimoto’s thyroiditis | 0.6 | 1.7 | |
| • Autoimmune hepatitis | 0.6 | 0 | |
| • Rheumatic fever | 0.6 | 0 | |
| • Inflammatory bowel disease | 0.6 | 1.1 | |
| • Sjogren syndrome | 0.6 | 1.7 |
Significant p-values are in bold.
Note: % Autoimmune diseases add up to higher % than the overall prevalence as some patients had multiple autoimmune diseases.
Abbreviation: ANA, anti-nuclear antibody; POAG, primary open angle glaucoma.