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. 2022 Feb 4;13:821542. doi: 10.3389/fimmu.2022.821542

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Copyright © 2022 Du, Zhu, Jiao, Nian, Zhang, Zhou, Zheng, Tong, Wei and Fu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cytotoxic capability detection of iNK cells. (A) Gene set enrichment analysis (GSEA) revealed an increase in Natural Killer cell-mediated cytotoxicity (enrichment plot: NATURAL KILLER CELL MEDIATED CYTOTOXICITY, HSA04650) in pNK cells compared with dNK cells and three kinds of iNK cells (n = 4 per group). (B, C) The percentage of CD16⁺ NK cells in each group was tested by flow cytometry. Representative density plots (B) and statistical calculation of all samples (C). Data represent means ± SD. (D) Some of the NK cells mediated cytotoxicity-related genes were selected for heat map analysis (n = 4 per group). (E) The direct cytotoxicity of different NK cells toward K562, as measured by flow cytometry. Results are presented as the mean ± SEM. Data were analyzed by one-way ANOVA, and n ≥ 6 in each group (C, E). ***p < 0.005; ****p < 0.0001.