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. 2021 Nov 15;126(4):606–614. doi: 10.1038/s41416-021-01628-y

Fig. 4. Assessment of intratumoral CD8+ T cell function.

Fig. 4

Representative image of a haematoxylin–eosin staining and b multiplex fluorescence immunohistochemistry in pre-NAC tissue showing the distribution of CD8+ T cell subsets in the intratumoural and peritumoural areas: pink arrows (CD8+ Ki-67+), cyan arrows (CD8+ PD-1+), and magenta arrows (CD8+PD-1+TIM3+). c Comparisons of the proportions of Ki-67+, PD-1+ and PD-1+TIM3+ among CD8+ T cells in the intratumoural and peritumoural areas between the responder and non-responder groups. The proportion of Ki-67+CD8+ T cells within the CD8+ T cells in pre-NAC tissue was significantly higher in the responder group than in non-responder group (p = 0.0413).