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. 2022 Feb 17;12:2776. doi: 10.1038/s41598-022-06824-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Anti-inflammatory effects of AdMSCs-derived exosomes via ROCK1/PTEN pathway. (a) The expression levels of ROCK1 and PTEN were quantified by real time-qPCR after treatment with ROCK1 and PTEN inhibitor. (b) THP-1 cells were treated with 100 ng/mL LPS (L), LPS + 5 μg/mL exosomes (LE), LPS + exosomes + 10 nM ROCK1 inhibitor (LE + Ri), and LPS + exosomes + 1 nM PTEN inhibitor (LE + Pi). (c) Protein levels of ROCK1 and PTEN were analyzed by western blot. β-actin was used as controls. Relative protein levels were confirmed by quantification. (d) A schematic diagram of miR-124-3p binding sites in the 3’ UTR of ROCK1 mRNA. After treatment with exosomes, the relative level of miR-124-3p was determined in THP-1 cells by real time-qPCR. The data are expressed as the mean ± SD of three independent experiments. *Significant difference from untreated control (p < 0.05). **Significant difference from untreated control (p < 0.01).