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. 2022 Feb 17;12:2776. doi: 10.1038/s41598-022-06824-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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miR-146a and miR132 involve angiogenesis of HUVECs. (a) The expression of miR-146a and miR-132 in HUVECs transfected with the miR-146a (miR-146a(i)) or miR-132 inhibitor (miR-132(i)), as determined by real time-qPCR. (E; exosome) (b) The expression levels of vasohibin-1(VASH1), thrombospondin-1(THBS1), angiopoietin1(ANGPT1), and flk1(KDR) in HUVECs transfected with the miR-146a or/and miR-132 inhibitor, as evaluated by real time-qPCR. (c) Tube formation in HUVECs transfected with the miR-146a or/and miR-132 inhibitor was determined using matrigel assay (× 100 magnification, scale bar = 200 μm). The data are expressed as the mean ± SD of three independent experiments. *Significant difference from untreated control (p < 0.05). **Significant difference from untreated control (p < 0.01).