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. 2022 Feb 17;5:141. doi: 10.1038/s42003-022-03092-7

Fig. 4. Differentially expressed proteins linked to stress responses to pesticides.

Fig. 4

a Proteins differentially expressed between drones and workers which have functions linked to oxidative stress, detoxification, DNA repair, the heat-shock response, and immunity. Asterisks indicate that the protein was also differentially expressed in drone imidacloprid vs. control comparisons. Boxes represent the interquartile range, bars indicate the median, and whiskers span 1.5 times the interquartile range. Circle size is proportional to −log(p value) for the drone imidacloprid vs. acetone comparison. b Patterns of expression for HSP cognate 3, HSP beta 1, and 97 kDa HSP in drones and workers. Asterisks indicate that the comparison was significant at 5% global FDR (Benjamini Hochberg). c Pattern of expression of an uncharacterized protein best matching glutathione-S-transferase S1 in Drosophila melanogaster across pesticide treatments. Asterisks indicate that the comparison was significant at 5% global FDR (Benjamini Hochberg). d Patterns of expression of protein lethal (2) essential for life (Pl(2)el) and HSP70 Ab across pesticide treatments. Asterisks indicate that the comparison was significant at 5% global FDR (Benjamini-Hochberg). e Patterns of expression of 10 kDa HSP and HSP60, mitochondrial HSPs which are known to physically interact in a 1:1 stochiometric ratio. Asterisks indicate that the comparison was significant at 5% global FDR (Benjamini–Hochberg). Underlying data can be found in Supplementary Data 4, and summary statistics of these data are in Supplementary Data 5.