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. 2022 Feb 17;13:946. doi: 10.1038/s41467-022-28639-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — The correlation between the expression of the 375 differentially expressed plasma proteins and the available blood markers and blood cell counts in our cohort was evaluated. The overall number (and the percentage) of the DEPs which correlated (significance of p < 0.05, two-tailed, using Pearson’s correlation, GraphPad Prism) with each clinical measurement are shown in the top row. The heatmap shows the number of DEPs (and the percentage depicted by the heatmap colors), which correlated with each clinical parameter stratified by the functional annotations shown in Fig. 2. CRP showed the highest number of overall and function-specific correlations with the DEPs.