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. 2022 Feb 17;12:2699. doi: 10.1038/s41598-022-06369-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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KRAS G12C (c.34G>T) co-occurrence with other activating KRAS mutations in NSCLC patients. (A) A pie chart of KRAS mutations in 467 G12C-positive samples. 27 samples showed co-occurrence of KRAS c.34G>T with c.35G>T. 11 samples were positive for KRAS c.34G>T and activating mutation in another codon (codon 13 or 14). (B) Frequency of individual KRAS genotypes in 26 samples with KRAS c.34G>T and c.35G>T co-occurring mutations. (C) A simplified scheme of two KRAS alleles and the effect of c.34G>T and c.35G>T co-occurrence on KRAS genotype. Co-occurrence in cis translates to KRAS G12F, whereas in trans produces both KRAS G12C and G12V proteins. (D) KRAS G12C and G12V VAFs in the six tissue samples where these mutations co-occurred in trans.