Table 1.

Frequency of KRAS c.34G>T (G12C) alone or co-occurring with another actionable KRAS mutation in four independent datasets. KRASm (KRAS non-synonymous mutations).

KRAS mutation	Our study (2306 patients; 1084 KRASm patients)		TCGA Nat Genet 2016; LUAD (660 patients; 214 KRASm patients)a		TCGA PanCancer Atlas; LUAD (566 patients; 168 KRASm patients)b		MSKCC Cancer Discov 2017; metastatic LUAD (860 patients; 236 KRASm patients)c
	# patients	% patients	# patients	% patients	# patients	% patients	# patients	% patients
G12C	429	91.9	96	98.0	68	97.1	101	97.1
G12F	19	4.1	2	2.0	0	0.0	1	1.0
G12C & V14I	10	2.1	0	0.0	0	0.0	0	0.0
G12C & G12V	6	1.3	0	0.0	2	2.9	1	1.0
G12F & G12C	1	0.2	0	0.0	0	0.0	1	1.0
G12F & V14I	1	0.2	0	0.0	0	0.0	0	0.0
G12C & G13D	1	0.2	0	0.0	0	0.0	0	0.0
Total	467	100	98	100	70	100	104	100

^aCampbell et al.²⁸.

^bHoadley et al.²⁷.

^cJordan et al.²⁶.