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. 2022 Feb 4;13:835986. doi: 10.3389/fimmu.2022.835986

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Copyright © 2022 Xu, Zhang, Sathe, Jin, Guan, Sun, Xing, Zhang and Yan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Single-cell analyses show macrophage subsets in murine alveolar bone after orthodontic force application. (A) UMAP plot of cells in OTM group. 8 (0 to 7) clusters were identified. Dimensional reduction was performed with principal component analysis (PCA) and visualization using UMAP plots. (B) Dot plot of conserved differentially expressed genes in each cluster. (C) Feature plots depicting single-cell gene expression of individual genes. (D) Proportions of 8 different macrophage clusters. (E) The top 60-65 markers (adj. p-value < 0.05) per cluster were used to identify the functional enrichment categories using Metascape. Pathway enrichment is expressed as the -log10(P-adjusted) for multiple comparison.