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Expression of ZO-1 in the intestinal epithelium as observed via immunohistochemistry. ZO-1 expression in the (A) normal, (B) DSS, (C) anti-TNF-α and (D) 5-ASA groups. Anti-TNF-α and 5-ASA increased the expression of ZO-1 in the intestinal epithelium of mice with DSS-induced colitis. Long-tailed arrows indicate ZO-1 expression. DSS, dextran sulfate sodium; 5-ASA, 5-aminosalicyclic acid; ZO-1, zona occludens-1.
