Table I.
Overall characteristics and test results in two groups.
| Groups | ||||
|---|---|---|---|---|
|
|
||||
| Characteristic | Patients with BC | SG | CG | P-value |
| Total patients | 215a | 38 (17.7)b | 177 (82.3)b | |
| Age at testing, years | 0.3173 | |||
| Mean ± SD | 47.5±10.6 | 47.4±9.9 | 47.5±11.0 | |
| Median, range | 47 (27–76) | 47 (32–68) | 47 (27–76) | |
| FH of cancer, n (%) | ||||
| None | 29 (13.4) | 4 (10.5) | 25 (14.1) | 0.7900 |
| FH of BC | 107 (49.7) | 17 (44.7) | 90 (50.8) | 0.5900 |
| FH of other cancer(s) | 79 (36.7) | 17 (44.7) | 62 (35.0) | 0.2700 |
| Multigene test result, n (%) | ||||
| Negative | 79 (36.7) | 13 (34.2) | 66 (37.3) | 0.8500 |
| Positive | 34 (15.8) | 5 (13.2) | 29 (16.4) | 0.8000 |
| VUS only | 102 (47.4) | 20 (52.6) | 82 (46.3) | 0.5900 |
| Positive in gene categories, n (%) | ||||
| NCCN absolute risk category | 13 (37.1) | 1 (20.0) | 12 (41.4) | 0.6200 |
| >60% | ||||
| NCCN absolute risk category | 2 (0.5) | 0 | 2 (6.9) | 1.0000 |
| 41-60% | ||||
| NCCN absolute risk category | 19 (55.8) | 4 (80.0) | 15 (51.7) | 0.6200 |
| 15-40% and low/unknown risk | ||||
a
Data are presented as the n;
b
data are presented as the n (%). BC, breast cancer; FH, family history; SG, study group; CG, control group; VUS, variant of uncertain significance; NCCN, The National Comprehensive Cancer Network.