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. 2022 Feb 17;5(2):e2148940. doi: 10.1001/jamanetworkopen.2021.48940

Table 2. Associations of eGFRdiffcys-cr With End-stage Kidney Disease Risk, Using Fine and Gray Proportional Subhazards Models With Mortality as Competing Risk .

Measure Demographic-adjusteda Fully adjustedb
Subhazard ratio (95% CI) P value Subhazard ratio (95% CI) P value
Baseline measures
Categorical eGFRdiffcys-cr, mL/min/1.73 m2
< −15 1.61 (1.14-2.26) .006 1.00 (0.65-1.52) .99
−15 to 15 1 [Reference] NA 1 [Reference] NA
≥15 0.51 (0.42-0.62) <.001 0.73 (0.59-0.89) .002
<−15 vs ≥15 3.15 (2.18-4.56) <.001 1.37 (0.87-2.16) .17
Time-updated measuresc
Categorical eGFRdiffcys-cr, mL/min/1.73 m2
<−15 2.06 (1.18-3.58) .01 1.83 (1.10-3.04) .02
−15 to 15 1 [Reference] NA 1 [Reference] NA
≥15 0.39 (0.27-0.58) <.001 0.50 (0.35-0.71) <.001
<−15 vs ≥15 5.25 (2.78-9.94) <.001 3.70 (2.05-6.65) <.001
Slope of eGFRdiffcys-cr, mL/min/1.73 m2/yd
Tertile 1, −7.9 to <−0.8 1.26 (1.05-1.52) .01 1.19 (0.98-1.46) .08
Tertile 2, −0.8 to −0.06 1 [Reference] NA 1 [Reference] NA
Tertile 3, >−0.06 to 24.2 0.78 (0.63-0.95) .01 0.86 (0.70-1.06) .16
Tertile 1 vs tertile 3 1.63 (1.31-2.02) <.001 1.39 (1.12-1.71) .002

Abbreviations: eGFRdiffcys-cr, difference between cystatin C– and creatinine-based estimated glomerular filtration rate; ESKD, end-stage kidney disease; NA, not applicable.

a

Demographic-adjusted model: adjusted for age, sex, race or ethnicity, and creatinine-based eGFR.

b

Fully adjusted model: adjusted for demographic-adjusted model and diabetes, hypertension, cardiovascular disease, heart failure, amputation, chronic obstructive pulmonary disease, angiotensin-converting enzyme or angiotensin-receptor blocker, steroids, log urine protein-to-creatinine ratio, and waist circumference.

c

All covariates are from the baseline examination except creatinine-based eGFR, urine protein-to-creatinine ratio, waist circumference, and eGFRdiffcys-cr, which were time-updated.

d

Within-participant slopes were estimated from a joint model of eGFR trajectory and survival or dropout. In slope models, all covariates were from baseline examination except creatinine-based eGFR, urine protein-to-creatinine ratio, and waist circumference, which were time-updated.