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CTCF-mediated chromatin looping provides a topological framework for the formation of transcriptional condensates via LLPS. Chromatin looping mediated by loop-extrusion provides a spatial framework for the accumulation of transcriptional factors, coactivators, and RNA polymerase II. Sufficient enrichment of transcription machinery components within this pre-looped topology drives the formation of transcriptional condensates via LLPS.
