Table 1.

t-Test analysis for stromal computational signatures. PSA, Proportionated Stromal Area; ISP, Immature Stromal Percentage; Myxoid Stromal Ratio; TIL, Tumor Infiltrating Lymphocytes; MMR, Mismatch repair; KRAS, Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; BRAF, B-Raf Proto-Oncogene. Significant features (p≤0.05) are shown in bold.

Ratio/Percentage	PSA	p value	ISP	p value	MSR	p value
Variable	Mean		Mean		Mean
Age		0.081		0.070		0.077
<=65	1.009		11.99		0.265
>65	0.831		7.103		0.151
Gender		0.887		0.377		0.648
Male	0.905		7.947		0.201
Female	0.890		10.32		0.197
Tumor budding		0.008		0.086		0.055
TBD1	1.052		6.160		0.120
TBD2 or TBD3	0.793		10.72		0.242
Pathological stage		0.010		0.129		0.092
≤ PT2	1.121		5.236		0.097
PT3–PT4	0.828		10.01		0.222
TIL		0.829		0.262		0.227
Low	0.887		7.668		0.189
High	0.912		10.83		0.201
Lymph node sStage		0.397		0.363		0.398
N0	0.935		10.01		0.218
N1–2	0.852		7.61		0.165
Tumor grade		0.635		0.246		0.192
G1–2	0.911		7.977		0.168
G3	0.858		11.42		0.261
Stromal differentiation		0.576		<0.001		<0.001
Immature/intermediate	0.871		15.91		0.347
Mature	0.927		0.322		0.004
MMR		0.013		0.005		0.022
Intact	0.962		7.183		0.154
Deficient	0.679		17.01		0.321
KRAS		0.712		0.951		0.983
Wild type	0.858		7.738		0.173
Mutation	0.779		7.350		0.170
BRAF		0.662		0.238		0.297
Wild type	0.958		9.075		0.187
Mutation	0.750		0.000		0.000