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. Author manuscript; available in PMC: 2022 Feb 18.
Published in final edited form as: Curr Opin Pharmacol. 2010 May 1;10(3):294–299. doi: 10.1016/j.coph.2010.04.003

Figure 3:

Figure 3:

Effect of sodium reabsorption on HS-mediated ASL height. (A) Experimental data of hypertonic saline (at 8μg NaCl/cm2/min) in the absence and presence of a potent sodium channel blocker (VX-371 at 50 μg/ml). (B) Mathematical model predicting the results of HS effect with normal ENaC conductance (solid line, consistent with experimental data) and 15% of ENaC channel normal conductance (dashed line).