Fig. 3. Epileptic spasms occur with variable frequency in Cdkl5 mutant mice.

(A) Occurrence of epileptic spasms in +/+ (n = 8), Cdkl5^R59X/+ (n = 7), and Cdkl5^KO/+ (n = 9) mice over three days. Black boxes indicate days with one or more detected epileptic spasms. (B) Comparison of spasm occurrence over three days in +/+, Cdkl5^R59X/+, and Cdkl5^KO/+ mice. For each mouse, the number of days (out of three total days) with one or more epileptic spasms was quantified. Mann-Whitney tests with Holm's correction for multiple comparisons (+/+ vs Cdkl5^R59X/+, p = .018; +/+ vs Cdkl5^KO/+, p = .023). (C) Estimated daily spasm burden is compared across +/+, Cdkl5^R59X/+, and Cdkl5^KO/+ mice. For each mouse, spasms were counted for a randomly selected day. Mann-Whitney tests with Holm's correction for multiple comparisons (+/+ vs Cdkl5^R59X/+, p = .011; +/+ vs Cdkl5^KO/+, p = .019).