Figure 7.

The effect of various treatments on the survival time of mice with brain metastasis.

Data are presented as mean ± standard deviation. Borneol combined with tetrandrine significantly prolonged the survival of 5-FU-treated mice with brain metastasis. Moreover, the borneol + tetrandrine + 5-FU-treated mice survived longer than mice in the untreated control group. Doses of 10 mg/kg 5-FU, 300 mg/kg borneol, and 10 mg/kg tetrandrine were used in the experiment. *P < .05, log-rank test indicates a significant difference compared to each group.

Abbreviations: 5-FU + BN: 5-FU combined with borneol; 5-FU + TT, 5-FU combined with tetrandrine; 5-FU + BN + TT, 5-FU combined with borneol and tetrandrine.