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. Author manuscript; available in PMC: 2023 Feb 1.
Published in final edited form as: J Immunol. 2022 Jan 14;208(3):745–752. doi: 10.4049/jimmunol.1901171

FIGURE 2.

FIGURE 2.

WT Bone marrow transplantation partially rescues the survival and intestine inflammation in CFTRΔF508 mice. (A) the survival curve of CFTRΔF508 mice (700 rads) transplanted with WT (green curve, n=9;) or CFTRΔF508 (orange curve, n=5) BM. (B) Typical H&E staining images of intestines from CFTRΔF508 mice transplanted with CFTRΔF508 or WT BM. (C-D) Quantification of crypts (C, Mean±SD of n=9) and villi (D, Mean±SD of n=27) height of intestines from CFTRΔF508 mice transplanted with CFTRΔF508 or WT BM. n=9. (E) A typical PAS staining image of intestine from a CFTRΔF508 mouse transplanted with WT BM. White arrows indicate mucus in crypts. (F) Percentage of intestine crypts that contain mucus in it. CFTRΔF508 mice are transplanted with WT or CFTRΔF508 BM. Mean±SD of n=27. n.s. p>0.05, *p<0.05, **p<0.01in the Gehan-Breslow-Wilcoxon test (A) and student t-test (C-D,F). Scale bars are 100 μm.