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. 2022 Feb 17;23:144. doi: 10.1186/s12864-022-08312-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Association between changes in expression and changes in methylation. a & b Plots depicting correlations between changes in methylation (methylation difference) and changes in expression (Log2FoldChange), for (a) DMCs or (b) DMRs overlapping an annotated gene. Panels on the left show association of DMCs/DMRs with DEGs, panels on the right correspond to DMC−/DMR-overlaps with genes, whose expression was not significantly altered by cold. Different colors indicate differential methylation in the three sequence contexts, with CpG in green, CHG in turquoise and CHH in purple