Fig. 5.

Prophylactic effects of F61 or F61/H121 antibodies against the omicron SARS-CoV-2 (B.1.1.529) variant in K18-hACE2 mice. Body weights, survival curves, and viral RNA loads in the lungs of K18-hACE2 mice treated with difference doses of antibodies (5, 20 ​mg/kg) F61 or F61+H121 via intranasal route before infection with 200 TCID₅₀ (A) or 1000 TCID₅₀ (B) omicron variant. As a negative control, PBS was administered (A, B). Body weight curve values represent means ​± ​standard errors of the means (n ​= ​3–4 mice/group). Significant differences between the antibody treatment group and negative control are shown. All data points for viral load in the lungs are shown, along with the medians. ns, P ​> ​0.05; ∗, P ​< ​0.05; ∗∗, P ​< ​0.0001, as determined by Student's t-test. Limit of detection (LOD), 500 copies/mL.