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. Author manuscript; available in PMC: 2023 Feb 4.
Published in final edited form as: J Proteome Res. 2022 Jan 19;21(2):519–534. doi: 10.1021/acs.jproteome.1c00912

Figure 1 – Metabolomics analyses of red blood cells, plasma, liver and spleen following irradiation.

Figure 1 –

We performed metabolomics analyses of red blood cells (RBCs), plasma and organs where erythrophagocytosis occurs, spleen and liver as a function of irradiation (untreated: 0; or irradiated: from 7 to 11 Gy – A). Heat maps of metabolites significant by ANOVA are shown in B. Data suggest progressive damage to RBC energy and redox systems, which corresponds to increased metabolic changes at higher irradiation doses in spleen and liver (C). A representative principal component analysis of RBCs exposed to increasing doses of irradiation (D). Results point at a significant impact of irradiation on glycolytic (E), polyamine (overview of the pathway in F, bar plots in G) and sulfur/amino acid metabolism in the spleen. We report alteration of glycolysis, taurine (H) and purine (J) metabolism in RBCs of irradiated mice.