| Methods |
Single site cross‐over randomized trial. Blinding of randomization: yes. Blinding of intervention: yes. Complete follow‐up: yes. Blinding of outcome measurement: yes. |
| Participants |
Total number of patients entered into the study: 18. Entry criteria: low birth weight premature infants, gestational age ranged 30‐37 weeks, postnatal age less than 4 weeks, requiring PN for at least two weeks. Exclusion criteria: inborn genetic error or significant organ failure. |
| Interventions |
After a 3‐day PN without cysteine, infants were randomly allocated to one of six successive schedules dosing schedules of cysteine hydrochloride for 3 days, ranging between 0 and 40 mg/g amino acids. For this systematic review we compared the levels of cyst(e)ine at the end of the schedule with the highest amount of cysteine intake (40 mg of cysteine hydrochloride per g of amino acid) (treatment, n = 18) versus the levels at the end of the lowest, i.e., 0 mg/g (control, n = 18). |
| Outcomes |
Plasma levels of taurine, cystine and methionine at the end of each successive schedule. |
| Notes |
Abstract only. Target PN dosage was 2.5 g/kg of amino acids with total caloric intake of 135 kcal/kg/day.
Setting: United States. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Adequate sequence generation? |
Unclear risk |
Single site cross‐over randomized trial
Blinding of randomization: yes |
| Allocation concealment? |
Low risk |
Blinding of randomization: yes |
| Blinding?
All outcomes |
Low risk |
Blinding of intervention: yes
Blinding of outcome measurement: yes |
| Incomplete outcome data addressed?
All outcomes |
Low risk |
Complete follow‐up: yes |
