NCT00254176.

Trial name or title	Cysteine Supplementation in Critically Ill Neonates
Methods	Treatment, Randomized, Double Blind (Subject, Caregiver, Investigator), Placebo Control, Single Group Assignment, Bio‐availability Study
Participants	Mechanically ventilated neonates of all gestational ages and birth weights, less than 1 month of postnatal age admitted to the NICU, SNAP (Score of Neonatal Acute Physiology) > 10, projected requirement for continued parenteral nutrition of at least 1 week duration
Interventions	Random allocation to receive a cysteine or an isonitrogenous cysteine‐free supplement to their TPN (total parenteral nutrition) regimen
Outcomes	Primary Outcome Measures:Total RBC glutathione Secondary Outcome Measures: Tumor necrosis factor (TNF), l Interleukin‐6 (IL‐6), Oxygen dependency, Ventilation dependency, Erythrocyte oxidized: reduced glutathione ratio, In vivo erythrocyte glutathione synthetic rate, Plasma malondialdehyde concentration
Starting date	September 2006
Contact information	sshew@mednet.ucla.edu
Notes

Cysteine supplementation in critically ill neonates

Sponsor: University of California, Los Angeles NCT 00254176