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Inhibition of PAI-1 activity by Nb42 and Nb64. A, Maximum inhibition of the activity of free or vitronectin-bound (+Vn) PAI-1-wt, by Nb42 and Nb64 in the presence of tPA (black bars) or uPA (white bars). B, IC50 values for the inhibition of free or Vn-bound (+Vn) PAI-1-wt by Nb42 and Nb64 in the presence of tPA (black bars) or uPA (white bars). All data are represented as mean ± SD; n ≥ 3. ** P < 0.01, **** P < 0.0001
