FIG. 4.

Kinetics of the parvovirus B19 DNA load in serum, hemoglobin values, and reticulocyte counts in an immunosuppressed child with underlying systemic onset of JIA (++, severe symptoms; +, moderate symptoms; −, no symptoms) and relapsing B19 infection. Day 0 indicates the first PCR-based diagnosis of an active B19 infection. B19 genome equivalents were calculated on the basis of an external plasmid standard. Treatments include packed red cells (PRC), prednisone (Pred; arrows indicate an increasing or decreasing dose), i.v. IgG containing antibodies specific for B19 VP-1, i.v. methotrexate (MTX), and discontinuation of cyclosporine (CSA%), as part of the immunosuppressive regimen.