Figure 5. 4PBA treatment does not improve bone strength.

Effect of daily injections of PBS (circle dots) or 0.4 mg 4PBA in PBS (filled square dots) for 4 weeks on biomechanical parameters of the same femora as in Figure 4 (4-point bending test at mid-shaft). Data are shown as mean ± SEM. Two-way ANOVA was used for max stiffness (treatment-genotype interaction, P > 0.1); Mann-Whitney U test was used for yield load, yield displacement, and work to fracture (failed normality test); and 2-tailed Student’s t test was used for post yield displacement and max load (failed equal variance test).