Figure 3. Kinetics of transferred and endogenous pan-coronavirus antibodies.

Plasma from 4 recipients (R1–R4) was subjected to VirScan, a phage-display library of epitopes from various coronaviruses, including SARS-CoV-2. Fold change (FC) was measured for antibody subsets in recipient plasma (each line represents a single antibody subset): donor antibodies (red) and endogenous antibodies (blue). Note that participants R1, R2, and R4, who developed SARS-CoV-2 infection, demonstrate endogenous antibody production. However, participant R3, who remained asymptomatic and SARS-CoV-2 PCR negative throughout the study period, did not develop an endogenous response.