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. 2022 Jan 25;7(2):e151518. doi: 10.1172/jci.insight.151518

Figure 4. Transfer of pan-coronavirus immunodominant antibodies.

Figure 4

Plasma from 4 donor-recipient pairs (R1–R4) were subjected to VirScan, a phage-display library of epitopes from various coronaviruses, including SARS-CoV-2 and the 4 endemic coronaviruses (NL63, OC43, 229E, and HKU1). (A) Donor and recipient convalescent antibody reactivities to SARS-CoV-2 spike protein. (B) The number of antibodies targeting pan-coronavirus immunodominant epitopes is presented for each group. Only antibodies unique to each group are shown. Immunodominant epitopes were previously defined (17): receptor binding domain (RBD), S1/S2 cleavage site (CS), fusion peptide (FP), heptad repeat (HR), and nucleocapsid protein (N).