Skip to main content
. 2022 Jan 25;7(2):e155432. doi: 10.1172/jci.insight.155432

Figure 2. Chronic HCV progression associates with elevated activation of iNKT cells.

Figure 2

PBMC samples from the acute phase of HCV infection from chronic progressors (n = 15) and resolvers (n = 15) were analyzed by flow cytometry. Samples with less than 20 iNKT cells were excluded from phenotypical analysis. (A and B) Percentage of CD38+ iNKT cells at indicated time points after ETI in resolvers (A) and progressors (B). Each dot represents an individual sample, and each line shows the overall trend for an individual patient over time calculated by linear regression analysis. Patients with more than 2 time points available were included in the analysis. (C and D) Correlation of alanine transaminase (ALT) levels with the frequency of CD38+ iNKT cells in all patients with known ALT level in the first year after ETI that either resolved (C) and progressed to chronic HCV (D). Pearson correlation analysis was used. (E and F) Correlation of ALT levels with the frequency of CD69+ iNKT cells in all patients with known ALT level in the first year after ETI that either resolved (E) or progressed to chronic HCV (F). Pearson correlation analysis was used.