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. 2022 Feb 8;7(3):e156236. doi: 10.1172/jci.insight.156236

Figure 5. Depletion of macrophages and monocytes ameliorates TTS-like cardiomyopathy in mice.

Figure 5

(A) Cardiac function in mice pretreated with clodronate-liposomes (CL) or PBS-liposome (PBS). n = 10. (B) Cardiac function in CCR2-KO and WT mice. n = 5. (C) Cardiac function in WT mice pretreated with RS-504393 (RS; 2 mg/kg twice daily by oral gavage) or PBS (Veh). n = 14. (D) Representative FACS plots of myocardial cells. Mice were pretreated with CL or RS for 3 days before ISO injection. P1, macrophages; P2, neutrophils. (E and F) Changes in cardiac macrophages (E) and neutrophils (F). n = 5–10. (A–C) P value from 2-tailed unpaired Student t test. (E and F) P values were from a 1-way ANOVA post hoc test with Tukey correction.