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. 2022 Feb 8;7(3):e156236. doi: 10.1172/jci.insight.156236

Figure 6. Genetic model of myeloid inhibition ameliorates ISO-induced TTS-like cardiomyopathy.

Figure 6

(A) Representative FACS plots of myocardial cells from Lyz2-Cre (Cre) and Lyz2-Hif1α-KO (KO) mice. P1, macrophages; P2, neutrophils. (B and C) Changes in cardiac macrophages (B) and neutrophils (C). n = 5–7. (D) Plasma cTnT levels. n = 5–9. (E) Cardiac function in ISO-treated Cre and KO mice. n = 5–10. All studies were performed at day 1 after ISO. (B–D) P values are from a 2-way ANOVA post hoc test with Tukey correction. (E) P value is from 2-tailed unpaired Student t test.