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. 2021 Dec 17;21(3):247–260. doi: 10.1080/15384101.2021.2015671

Figure 1.

Figure 1.

CircGOT1 and its host gene GOT1 upregulated and associated with poor prognosis of ESCC. (a-d). The qPCR analysis was used to validate the expression of circGOT1 in 68 ESCC tissues and matched normal tissues with different size (≥5 cm, n = 35; ≤5 cm, n = 33), tumor grades (G1, n = 32; G2, n = 20; G3, n = 16) and pathological stages (T1+ T2, n = 33; T3+ T4, n = 35). (e-h). The qPCR analysis was use to examine the expression of GOT1 in 68 ESCC tissues and matched normal tissues with different size (≥5 cm, n = 35; ≤5 cm, n = 33), tumor grades (G1, n = 32; G2, n = 20; G3, n = 16) and pathological stages (T1+ T2, n = 33; T3+ T4, n = 35). (i-j). The Kaplan-Meier survival curves analysis indicate the high and low expression of circGOT1 and GOT1 associated overall survival. (k-l). The qPCR analysis was used to detect the expression of circGOT1 and GOT1 in WSCC cell lines (KYSE150, KYSE510, TE1, TE5, and TE13) and human normal esophageal epithelial cells HEEC. **P < 0.01; ***P < 0.001.