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. 2021 Dec 17;21(3):247–260. doi: 10.1080/15384101.2021.2015671

Figure 7.

Figure 7.

CircGOT1 exerted carcinogenesis in ESCC by regulating miR-606/GOT1 axis. (a-b). CCK-8 assay was used to detect the cell viability after circGOT1 knockdown and then restored by miR-606 inhibition or GOT1 upregulation. (c-d) Transwell was used to determine the migrated cells after circGOT1 knockdown and then restored by miR-606 inhibition or GOT1 upregulation. (e-f). The qPCR was used to detect the expression of E-cadherin, N-cadherin, and vimentin after circGOT1 knockdown and then restored by miR-606 inhibition or GOT1 upregulation. (g-h). The qPCR was used to examine the expression of Bcl-2, Bax, and caspase 3 after circGOT1 knockdown and then restored by miR-606 inhibition or GOT1 upregulation. (i-k). The glycolytic levels were determined by glucose uptake, lactate production, and ATP levels after circGOT1 knockdown and then restored by miR-606 inhibition or GOT1 upregulation. (l-n). The protein levels of PKM, HK2, and DHA were detected by Western blotting after circGOT1 knockdown and then restored by miR-606 inhibition or GOT1 upregulation. **P < 0.01; ***P < 0.001.