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. 2022 Jan 10;21(3):304–321. doi: 10.1080/15384101.2021.2020041

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 4. — Circ-PITX1 enhanced ITGA6’s expression. (a) The GEPIA (http://gepia.cancer-pku.cn/detail.php) database determined ITGA6’s expression in lung squamous cell carcinoma (LUSC). b–c. The Human Protein atlas (http://gepia.cancer-pku.cn/detail.php) confirmed ITGA6 expression in normal lung tissues or lung cancer tissues. A higher level of ITGA6 intricately pertained to the poorer overall survival of lung cancer patients. D-F. RT-PCR and Western blot measured the mRNA and protein levels of ITGA6, p-PI3K and p-Akt in NSCLC cells up-regulating circ-PITX1 or down-regulating circ-PITX1. G: IHC testified ITGA6 expression in tumor tissues. **P < 0.01 (vs.Vector group). &&P < 0.01, &&&P < 0.001 (vs.si-NC group), n = 3.