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. 2022 Jan 10;21(3):304–321. doi: 10.1080/15384101.2021.2020041

Figure 6.

Figure 6.

miR-30e-5p exerted an inhibitory function in NSCLC development. (a) H1975 and A549 cells were transfected along with miR-30e-5p mimics or the miR-30e-5p inhibitor, with miR-30e-5p’s level confirmed by RT-PCR. B and C. CCK-8 (b) and colony formation assay (c) examined cell proliferation, NS P > 0.05, *P < 0.05, **P < 0.01. ***P < 0.001 vs. the miR-NC group or the si-NC group. (d) TUNEL assay checked cell apoptosis. E and F. Tranwell tracked cell migration (e) and invasion (f). * P < 0.05, **P < 0.01, ***P < 0.001. g–i. Western blot measured the protein levels of EMT markers (g), apoptosis-related proteins (h), ITGA6, p-PI3K and p-Akt (i). **P < 0.01, ***P < 0.001(vs.miR-NC group). &&P < 0.01, &&&P < 0.001(vs.NC-in group). n = 3.