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. 2022 Jan 10;21(3):304–321. doi: 10.1080/15384101.2021.2020041

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 7. — Circ-PITX1 sponged miR-30e-5p to modulate NSCLC cell proliferation and metastasis. a and b. H1975 cells were transfected together with miR-30e-5p mimics and/or circ-PITX1 overexpression plasmid. RT-PCR confirmed the levels of circ-PITX1 (a) and miR-30e-5p (b). (c). Western blot checked ITGA6, p-PI3K and p-Akt expression. d and e. CCK-8 (d) and colony formation assay (e) monitored cell proliferation. (f) TUNEL staining was adopted to examine the TUNEL-positive cell number. (g) WB determined the profiles of Bax, Bcl-2 and c-Caspase3. (h) Tranwell assay tracked cell migration and invasion. (i) Western blot determined the protein levels of EMT markers (E-cadherin, Vimentin, and N-cadherin). **P < 0.01, ***P < 0.001 (vs.Vector group), && P < 0.01, &&&P < 0.001 (vs.circ-PITX1 group), n = 3.