TABLE 3.
Multivariable adjusted a hazard ratios (HRs) for all‐cause mortality according to prediagnostic systolic and diastolic blood pressure among patients with prostate cancer by the type of treatment (curative and endocrine prostate cancer treatment). The PROCA‐life study (1994–2018)
| All prostate cancer | Curative treatment | Endocrine treatment | ||||
|---|---|---|---|---|---|---|
| Number of deaths/cases | 265/798 | Number of deaths/cases | 86/476 | Number of deaths/cases | 168/292 | |
| HR (95% CI) | HR (95% CI) | HR (95% CI) | ||||
| Systolic blood pressure (mmHg) | ||||||
| <130 | 67/296 | 1.00 (reference) | 22/196 | 1.00 (reference) | 44/94 | 1.00 (reference) |
| 130–139.9 | 60/221 | 1.08 (0.75–1.55) | 21/112 | 1.11 (0.59–2.08) | 40/72 | 0.87 (0.55–1.36) |
| 140–149.9 | 46/121 | 0.97 (0.65–1.47) | 17/70 | 1.58 (0.81–3.10) | 30/48 | 0.91 (0.55–1.51) |
| ≥150 | 92/173 | 1.35 (0.96–1.90) | 26/82 | 1.83 (0.99–3.40) | 54/78 | 1.11 (0.73–1.71) |
| p for trend b | 0.091 | 0.029 | 0.51 | |||
| Per SD increase | 1.14 (1.03–1.27) | 1.26 (1.03–1.55) | 1.14 (0.99–1.31) | |||
| Diastolic blood pressure (mmHg) | ||||||
| <80 | 110/404 | 1.00 (reference) | 32/238 | 1.00 (reference) | 74/125 | 1.00 (reference) |
| 80–89.9 | 75/227 | 1.08 (0.80–1.45) | 24/134 | 1.10 (0.64–1.88) | 48/94 | 0.98 (0.67–1.42) |
| 90–99.9 | 50/132 | 1.24 (0.87–1.75) | 20/80 | 1.75 (0.97–3.14) | 26/49 | 0.91 (0.57–1.45) |
| ≥100 | 30/48 | 1.85 (1.22–2.82) | 10/24 | 3.05 (1.42–6.55) | 20/24 | 2.15 (1.25–3.69) |
| p for trend b | 0.009 | 0.004 | 0.13 | |||
| Per SD increase | 1.17 (1.03–1.32) | 1.43 (1.17–1.75) | 1.12 (0.97–1.30) | |||
Statistically significant (p‐value < 0.05) hazard ratios are marked in bold letters. p‐value for linear trend in blood pressure categories are marked in italic letters.
a
Adjusted for age at baseline, body mass index (BMI, kg/m2), smoking, alcohol use, physical activity, diabetes, and education level.
b
p‐value for linear trend in blood pressure categories.