Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Hypoxia reprograms the immune functions of pDCs. The activation of pDCs in response to TLR9 stimulation is suppressed under hypoxic conditions, accompanied by impaired abilities of IFN‐α production and antigen presentation. Instead, hypoxia promotes the tolerogenic functions of pDCs, mainly including upregulated IDO expression and Treg induction
