Scheme 6. Synthesis of Bicalutamide-Based Degrader 46a.
aReaction conditions: (a) DMF, DIPEA, 110 °C, 12 h; (b) dichloromethane, TFA; and (c) 2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione, DMF, DIPEA, 90 °C, 12 h.
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