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. Author manuscript; available in PMC: 2022 Feb 18.
Published in final edited form as: J Med Chem. 2021 Sep 2;64(18):13487–13509. doi: 10.1021/acs.jmedchem.1c00900

Scheme 1. Synthesis of AR Degraders Containing a Linear Linkera.

Scheme 1.

aReaction conditions: (a) THF, NaH, 0 °C, 4 h; (b) dichloromethane, TFA; (c) dioxane, Pd2(dba)3, Xphos, Cs2CO3, 90 °C, 12 h; (d) 2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione, DMF, DIPEA, 90 °C, 12 h; and (e) dichloromethane, 52, HATU, DIPEA.