Table 3.
PKs of Compounds 26, 35, and 40–45 in Mice
| male mice | IV (mg/kg) | T1/2 (h) | AUC(0–t) (h*ng/mL) | Vss (L/kg) | Cl (L/h/kg) | PO (mg/kg) | Tmax (h) | T1/2 (h) | Cmax (ng/mL) | AUC(0–t) (h*ng/mL) | F (%) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 26 | 1 | 6.1 | 2425 | 3.0 | 0.4 | 3 | 4.0 | 5.6 | 207 | 2154 | 30 |
| 35 | 1 | 6.6 | 2857 | 2.7 | 0.3 | 3 | 5.3 | 10.6 | 251 | 3811 | 44 |
| 40 | 1 | 12.5 | 693 | 17.6 | 1.1 | 3 | 6.0 | 27.0 | 45 | 738 | 35 |
| 41 | 1 | 7.6 | 3366 | 2.6 | 0.3 | 3 | 4.7 | 7.0 | 256 | 3001 | 29 |
| 42 | 1 | 3.8 | 1226 | 3.9 | 0.8 | 3 | 5.3 | 4.3 | 127 | 1111 | 30 |
| 43 | 2 | 5.5 | 6481 | 1.8 | 0.3 | 5 | 2.0 | 4.6 | 1140 | 8254 | 51 |
| 44 | 1 | 8.8 | 1118 | 8.3 | 0.8 | 3 | 4.0 | 8.1 | 92.2 | 1134 | 34 |
| 45 | 1 | 7.5 | 4234 | 2.1 | 0.2 | 3 | 4.7 | 26.8 | 484 | 8637 | 67 |