. Author manuscript; available in PMC: 2022 Feb 18.

Published in final edited form as: J Med Chem. 2021 Sep 2;64(18):13487–13509. doi: 10.1021/acs.jmedchem.1c00900

Table 5.

Futrther Exploration of the Linker in Compound 35


Compound No	Linker	AR degradation in VCaP cell line
Compound No		DC₅₀ (nM)	D_max (%)

35		0.1	99
39		1.4	93
40		0.5	96
41		0.1	96
42		0.01	99
43		0.04	99
44		0.1	100
45		0.2	96