. Author manuscript; available in PMC: 2022 Feb 18.

Published in final edited form as: J Med Chem. 2021 Sep 2;64(18):13487–13509. doi: 10.1021/acs.jmedchem.1c00900

Table 8.

DC₅₀, D_max and IC₅₀ Values of Selected Compounds in the LNCaP Cell Line^a

	AR degradation in LNCaP cell line
Compound No	DC₅₀ (nM)	D_max (%)	IC₅₀ in LNCaP cell line (nM)
Enzalutamide	NA	NA	133 ± 5
ARV-110	1.5	99	33.1 ± 3.7
35	0.3	95	15.3 ± 3.7
41	0.4	95	22.3 ± 2.9
42	0.9	99	11.4 ± 2.2
43	0.1	98	16.2 ± 1.8
44	1.9	99	11.6 ± 2.0
45	1.3	64	21.7 ± 5.9

NA: not available. IC₅₀ value was determined by three independent experiments for each compound.