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. Author manuscript; available in PMC: 2022 Feb 18.
Published in final edited form as: Clin Exp Metastasis. 2017 Feb 17;34(2):185–196. doi: 10.1007/s10585-017-9839-9

Figure 1. Expression of Reelin in primary breast cancer and BBM cells is subtype and microenvironment specific.

Figure 1.

(a-c) Immunohistochemical analysis of Reelin expression in Her2+ and TN primary breast cancer tissue. Quantification of Her2 and Reelin is shown on right (n = 12, p ≤ 0.01, bars indicate SEM). (d-f) Immunohistochemical analysis of Reelin expression in Her2+ and TN BBM patient specimens. Quantification of Her2 and Reelin is shown on right (n = 3, p ≤ 0.01, bars indicate SEM). (g) Immunohistochemical analysis of spatial distribution of Reelin within Her2+ BBM tumor and within tumor periphery. Tumor periphery and peritumor regions are separated by blue and red dashed lines. Triangle in lower panel indicates expression gradient of Reelin from tumor core to tumor periphery (B = brain, T = tumor, PT= peritumor regions). (h) Immunohistochemical analysis of astrocyte in tumor periphery and peritumor regions of BBM tumor. Tumor periphery is separated by blue dashed lines. Red arrow indicate presence of infiltrative astrocyte within BBM tumor (B = brain, T = tumor)