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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Cancer Causes Control. 2021 Jan 23;32(4):347–355. doi: 10.1007/s10552-021-01391-8

Table 3.

Risk of glioma in the UK Biobank by baseline cholesterol concentrations with a four year lag period, stratified by sex.

Total Male Female
Quartile Range (mg/dL)* Cases^ MV HR† 95%CI Cases^ MV HR† 95%CI Cases^ MV HR‡ 95%CI
TC Q1 <190 49 Ref. 35 Ref. 14 Ref.
Q2 ≥190-218 53 1.39 0.91-2.12 30 1.30 0.76-2.22 23 1.40 0.69-2.84
Q3 ≥218-248 56 1.49 0.96-2.31 35 1.76 1.02-3.04 21 1.02 0.48-2.17
Q4 ≥248 71 1.86 1.21-2.88 40 2.26 1.32-3.89 31 1.28 0.61-2.68
P-trend 229 0.005 140 0.002 89 0.72
HDL-C Q1 <45 45 Ref. 37 Ref. 8 Ref.
Q2 ≥45-54 54 1.27 0.85-1.92 36 1.29 0.81-2.07 18 1.03 0.44-2.40
Q3 ≥54-65 56 1.46 0.96-2.21 26 1.30 0.77-2.20 30 1.26 0.57-2.81
Q4 ≥65 49 1.49 0.93-2.37 22 2.34 1.34-4.11 27 0.87 0.38-2.00
P-trend 204 0.09 121 0.006 83 0.53
LDL-C Q1 <114 56 Ref. 37 Ref. 19 Ref.
Q2 ≥114-136 44 0.94 0.61-1.45 27 0.98 0.57-1.69 17 0.85 0.43-1.71
Q3 ≥136-159 62 1.23 0.81-1.87 36 1.39 0.81-2.38 26 0.99 0.50-1.95
Q4 ≥159 66 1.33 0.87-2.04 39 1.53 0.89-2.64 27 1.01 0.51-2.01
P-trend 228 0.10 139 0.07 89 0.82
TG Q1 <92 53 Ref. 30 Ref. 23 Ref.
Q2 ≥92-131 66 0.98 0.67-1.42 38 1.03 0.63-1.68 28 0.91 0.50-1.63
Q3 ≥131-190 48 0.69 0.46-1.04 29 0.64 0.48-1.08 19 0.75 0.40-1.42
Q4 ≥190 62 0.88 0.60-1.31 43 0.82 0.50-1.34 19 1.00 0.52-1.91
P-trend 229 0.48 140 0.33 89 0.99
*

Quartiles for each cholesterol measure were computed using the distribution of values among participants in the UK Biobank.

^

Cases may not sum to total due to missing cholesterol values.

†

Adjusted for age, sex (male vs. female), race (White vs. non-White), education (secondary school vs. vocational training vs. some college vs. completed college vs. none of the above), history of hypertension (yes vs. no), history of diabetes (yes vs. no), BMI (≤25 kg/m2 vs. 25-30 kg/m2 vs. ≥30 kg/m2), smoking status (never vs. past vs. current), and statin use (current use vs. no current use).

‡

Adjusted for age, sex (male vs. female), race (White vs. non-White), education (secondary school vs. vocational training vs. some college vs. completed college vs. none of the above), history of hypertension (yes vs. no), history of diabetes (yes vs. no), BMI (≤25 kg/m2 vs. 25-30 kg/m2 vs. ≥30 kg/m2), and smoking status (never vs. past vs. current).

Abbreviations: BMI: body mass index, CI: confidence interval, HDL-C: high-density lipoprotein cholesterol, HR: hazard ratio, LDL-C: low-density lipoprotein cholesterol, MV: multivariable, TC: total cholesterol, TG: triglycerides