Table 5.
Comparison of predictive accuracy and cut-off values of TG/HDL-C, VAI, LAP, and TyG by age and sex for the total sample.
| AUC (95% CI) | p Value | Sensitivity | Specificity | Cut-off | Youden Index | |
|---|---|---|---|---|---|---|
| Overall | ||||||
| LAP | 0.806 (0.763–0.850)b-c | – | 0.696 | 0.804 | 48.70 | 0.500 |
| TyG | 0.800 (0.757–0.844)b-c | <.628 | 0.765 | 0.692 | 8.76 | 0.457 |
| TG/HDL-C | 0.773 (0.737–0.807)a | <.001 | 0.765 | 0.678 | 2.68 | 0.446 |
| VAI | 0.767 (0.721–0.813)a | <.001 | 0.661 | 0.764 | 2.41 | 0.427 |
| Age <48 | ||||||
| LAP | 0.811 (0.761–0.854)b-c | – | 0.667 | 0.846 | 48.70 | 0.513 |
| TyG | 0.807 (0.765–0.845)b-c | .760 | 0.804 | 0.643 | 8.62 | 0.447 |
| TG/HDL-C | 0.775 (0.722–0.821)a | .043 | 0.706 | 0.722 | 2.71 | 0.455 |
| VAI | 0.771 (0.718–0.818)a | .047 | 0.608 | 0.817 | 2.54 | 0.450 |
| Age ≥48 | ||||||
| LAP | 0.794 (0.741–0.840)b-c | – | 0.719 | 0.765 | 49.64 | 0.484 |
| TyG | 0.785 (0.732–0.832)b-c | .549 | 0.828 | 0.648 | 8.75 | 0.476 |
| TG/HDL-C | 0.760 (0.705–0.806)a | .015 | 0.750 | 0.700 | 2.87 | 0.449 |
| VAI | 0.752 (0.697–0.802)a | .010 | 0.828 | 0.601 | 2.08 | 0.429 |
| Men | ||||||
| LAP | 0.773 (0.728–0.814)b-c | – | 0.729 | 0.747 | 48.70 | 0.476 |
| TyG | 0.763 (0.718–0.805)b-c | .494 | 0.729 | 0.677 | 8.87 | 0.406 |
| TG/HDL-C | 0.732 (0.685–0.775)a | .004 | 0.718 | 0.703 | 3.11 | 0.421 |
| VAI | 0.735 (0.688–0.778)a | .004 | 0.729 | 0.673 | 2.54 | 0.403 |
| Women | ||||||
| LAP | 0.873 (0.816–0.917) | – | 0.900 | 0.688 | 29.25 | 0.588 |
| TyG | 0.877 (0.821–0.921)b-c | .854 | 0.933 | 0.695 | 8.50 | 0.628 |
| TG/HDL-C | 0.855 (0.795–0.902) | .334 | 0.900 | 0.714 | 2.00 | 0.614 |
| VAI | 0.855 (0.796–0.902) | .131 | 0.900 | 0.682 | 1.08 | 0.582 |
Note: a indicates a significant difference compared with TyG; b indicates a significant difference compared with TG/HDL-C; c indicates a significant difference compared with VAI.
P values are calculated by the nonparametric approach to compare AUC of other evaluated variables with LAP.
TG/HDL-C: triglyceride-to-HDL cholesterol ratio; TyG: triglycerides/glucose index; VAI: visceral adiposity index; LAP: lipid accumulation product; AUC: area under the receiver operating characteristic curve, respectively.