Skip to main content
. 2022 Feb 8;18(2):e1009862. doi: 10.1371/journal.ppat.1009862

Fig 7. Activating cAMP synthesis decreases liberation of propionyl-CoA from cholesterol.

Fig 7

(A) Relative GFP signal from the prpD’::GFP reporter in response to V-59 (10 μM) or DMSO treatment in murine macrophages or cholesterol media. Data are normalized to WT treated with DMSO (**P < 0.01, ***P < 0.001, Two-way ANOVA with Tukey’s multiple comparisons test). (B) Relative GFP signal from the prpD’::GFP reporter in response to inducing TetOn-cAMP with Atc treatment in murine macrophages or cholesterol media. Data are normalized to EtOH vehicle control (**P < 0.01, ***P < 0.001, One-way ANOVA with Dunnett’s multiple comparisons test). GFP MFI was quantified from 10,000 mCherry+ Mtb. Data are from two experiments with two technical replicates, shown as means ± SD.