Table 3.
Univariate or multivariate Cox regression analysis of clinicopathological features of LGGs associated with OS.
| Characteristics | Total (N) | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|---|
| Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | |||
| Diagnosis age | 461 | |||||
| ≧50 | 145 | Reference | ||||
| <50 | 316 | 0.320 (0.220-0.465) | <0.001 | 0.407 (0.239-0.695) | <0.001 | |
| Gender | 422 | |||||
| Female | 186 | Reference | ||||
| Male | 236 | 1.134 (0.769-1.673) | 0.525 | |||
| Grade | 422 | |||||
| II | 199 | Reference | ||||
| III | 223 | 3.323 (2.163-5.103) | <0.001 | 2.567 (1.410-4.672) | 0.002 | |
| IDH1 status | 248 | |||||
| Mutant | 189 | Reference | ||||
| Wild-type | 59 | 4.927 (3.009-8.067) | <0.001 | 2.465 (1.238-4.907) | 0.010 | |
| IDH2 status | 286 | |||||
| Wild-type | 274 | Reference | ||||
| Mutant | 12 | 1.121 (0.351-3.579) | 0.847 | |||
| Codel 1p/19q | 285 | |||||
| False | 200 | Reference | ||||
| True | 85 | 1.249 (0.755-2.067) | 0.386 | |||
| TERT promoter status | 284 | |||||
| Wild-type | 156 | Reference | ||||
| Mutant | 128 | 0.953 (0.586-1.551) | 0.848 | |||
| TP53 status | 286 | |||||
| Mutant | 146 | Reference | ||||
| Wild-type | 140 | 0.818 (0.505-1.324) | 0.414 | |||
| IRSS | 461 | 3.172 (2.559-3.932) | <0.001 | 1.565 (1.052-2.329) | 0.027 | |
CI: confidence interval; IDH: isocitrate dehydrogenase; IRSS: immune risk score signature; TP53: tumor protein p53; TERT: telomerase reverse transcriptase.