Table 2.

Diagnostic accuracy of serum BUN and BUN/creatinine ratio to identify patients with citrin deficiency.

Index	Timing	AUC	Cutoff	Sensitivity	Specificity	Positive LR	Negative LR
Serum BUN	First visit	0.94	13	0.78	0.89	6.8	0.3
			12	0.89	0.86	6.2	0.1
			11	1.00	0.86	7.0	0.0
			10	1.00	0.71	3.5	0.0
	≤60 days	0.80	13	0.30	0.91	3.2	0.8
			12	0.60	0.88	4.8	0.5
			11	0.70	0.75	2.8	0.4
			10	0.70	0.69	2.2	0.4
	≤100 days	0.98	13	0.50	0.97	17.5	0.5
			12	0.50	0.94	8.8	0.5
			11	0.70	0.83	4.1	0.4
			10	0.80	0.71	2.8	0.3
Serum BUN/creatinine ratio	First visit	0.78	80	0.11	0.97	3.9	0.9
			70	0.22	0.94	3.9	0.8
			60	0.33	0.91	3.9	0.7
			50	0.67	0.71	2.3	0.5
	≤60 days	0.81	80	0.50	0.97	16.0	0.5
			70	0.50	0.88	4.0	0.6
			60	0.60	0.72	2.1	0.6
			50	0.80	0.56	1.8	0.4
	≤100 days	0.85	80	0.70	0.97	24.5	0.3
			70	0.70	0.91	8.2	0.3
			60	0.70	0.77	3.1	0.4
			50	0.80	0.57	1.9	0.4

AUC, area under the curve; BUN, blood urea nitrogen; LR, likelihood ratio.